Advanced Light Microscopy (COM)

Advanced Light Microscopy Imaging Core at the Penn State Hershey provides training and consultation in ultra-high resolution imaging of cells and tissues in fixed or live states using high end multimodal light microscope systems. We also provide expert advice in quantitative image analysis and offer collaborative opportunities, including image processing, image analysis and data interpretation in microscopy related research projects. Our Confocal, Super-resolution STED and Deconvolution  Microscopes are useful in 3D imaging of any biological systems and spatial distribution of multiple fluorescently labelled sub-cellular objects including various cellular proteins complexes (multiple colors) simultaneously in live or fixed biological conditions. We are also equipped with a Multimodal Multiphoton Microscope which is capable of performing deep tissue fluorescence (multiple colors) and harmonic generation imaging in ex vivo, in vivo or intra-vital small animal imaging. Our IMARIS, VOLOCITY and HUYGENS Workstations are excellent tools for 3D reconstruction from a series of 2D optical sections as well as complex quantitative microscopy computations.