Transmission Electron Microscopy (COM)

Overview of Services

Our mission is to provide high-quality transmission electron microscopy (TEM) services, education, and training for the Penn State Hershey campus, other academic institutions, and private companies at-large.

The lab is equipped with high resolution transmission electron microscopes (JEOL 1400) and full suite of ancillary sample preparation equipment to fit most TEM-related needs. The equipment can provide nanometer scale analysis for biological, chemical and materials science. The TEM facility offers multiple levels of service that correspond with the services and training each user desires:

• Project consultation
• Education and training for new users
• Full service transmission electron microscopy.

TEM services include sample preparation, fixation, embedding, ultra-microtomy, staining, TEM imaging, immuno-localization (i.e. immunogold EM), and negative staining.

TEM Applications

TEM can be used to obtain details view of a specimen at atomic resolution level. For biological samples, TEM can give unambiguous identification of cellular compartments and organelles. In combination with specific molecular marker (e.g. antibody) and electron dense labels (immunogold particles or Nanoparticles), it is possible to identify association of a particular molecules with a specific organelle or with another type of molecules.

Leadership

Han Chen | Manager

Bruce Stanley | Scientific Director

Location and hours of operation

Links and Resources

• https://infonet.pennstatehershey.net/web/core/microscopy-imaging

Contacts