Mass Spectrometry & Proteomics (COM)

Overview of Services

Penn State College of Medicine's Mass Spectrometry & Proteomics Core provides sample prep and mass spectrometry analyses for the identification and quantitation of proteins, peptides, post-translational modifications, and therapeutic drugs, drug metabolites, lipids and other small molecules.

Other services include consultations and development of experimental methods, commercial and in-house developed biostatistical and bioinformatic software, separations of complex protein and/or peptide mixtures; both label-free and isotope-labeled protein expression analysis (e.g., iTraq, SILAC, SWATH/DIA label-free); and quantitation of cytokine, amino acid, drug, and other small-molecule levels.

After initial consultation with Core Facility staff to determine optimal methods to acheive their experimental goals, researchers submit their Sample Analysis Requests (including information about their samples and how samples were prepared) to our Laboratory Information Management System (LIMS) using the Excel Spreadsheets linked to here in iLabs. The sometimes large results datasets and analyses are subsequently posted to the same LIMS system, where they are archived and backed up for the researcher to download to their own computers

Funding for the instrumentation and software used by the Mass Spec and Proteomics Facility have been provided by a variety of sources, including NIH Shared Instrumentation Grants, Pennsylvania State CURE funds (Tobacco Settlement Funds), and the Penn State Cancer

Leadership

Location and hours of operation

Links and Resources

1. https://research.med.psu.edu/core-facilities/mass-spectrometry

Contacts